39.1 SCOPE vs STOP
- Outcomes: Prolactin, hPL, GH2, Insulin, HOME-IR, glucose (all outcomes log-transformed)
- Independent variables: Study, f39_gdm_new, BMI, Ethnicity (Caucasian/non-Caucasian), smoking (yes/no), GA at sampling
- Model fitted: LME or GEE model
log(hormones) ~ Study + GA at sampling + Study:GA at sampling
Random intercepts for Study ID and Plate
#outc_ls <- c("Prolactin","HPL","GH2")
outc_ls <- c(hormone_var,insulin_var)
outc2 <- preg_out
# fit LME
fit_ls <- lapply(outc_ls,function(outc){
if(outc%in%hormone_var){ #LME for hormones
fit_eq <- as.formula(paste0("log(",outc,")~ Study + ",outc2," + BMI + Ethnicity_cauc + f10c_any_cig_1st_vst + GA_samp + Study*",outc2," + (1|Study.ID) + (1|Assay.",outc,")"))
fit <- eval(bquote(lmer(.(fit_eq),data=dat_run)))}
if(outc%in%insulin_var){ #GEE for insulin
fit_eq <- as.formula(paste0("log(",outc,")~ Study + ",outc2,"+BMI+Ethnicity_cauc+f10c_any_cig_1st_vst+GA_samp+Study*",outc2))
dat_tmp <- na.omit(dat_run[with(dat_run,order(Study,Study.ID)),c("Study","Study.ID","GA_samp","BMI","Ethnicity_cauc","f10c_any_cig_1st_vst",outc,outc2)])
fit <- eval(bquote(geeglm(.(fit_eq),data=dat_tmp,id=Study.ID,corstr="independence")))}
return(fit)})
names(fit_ls) <- outc_ls
# Type III SS
anova_ls <- lapply(fit_ls,function(fit){
if(!any(class(fit)%in%"gee")){return(Anova(fit,type="III"))}
if(any(class(fit)%in%"gee")){return(joint_tests(fit,cov.reduce=symmint(0)))}})39.1.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
Prolactin| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 250.7924480 | 1 | <0.0001 | *** |
| Study | 3.2136720 | 1 | 0.07 | ns |
| f39_gdm_new | 0.5754347 | 1 | 0.4 | ns |
| BMI | 3.3368238 | 1 | 0.07 | ns |
| Ethnicity_cauc | 105.4219556 | 1 | <0.0001 | *** |
| f10c_any_cig_1st_vst | 49.1590682 | 1 | <0.0001 | *** |
| GA_samp | 164.6323095 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 1.8652579 | 1 | 0.2 | ns |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 150.8759535 | 1 | <0.0001 | *** |
| Study | 7.3986291 | 1 | 0.007 | ** |
| f39_gdm_new | 0.4357432 | 1 | 0.5 | ns |
| BMI | 236.2094019 | 1 | <0.0001 | *** |
| Ethnicity_cauc | 5.5165373 | 1 | 0.02 | * |
| f10c_any_cig_1st_vst | 0.9176455 | 1 | 0.3 | ns |
| GA_samp | 2601.9722143 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 1.4845286 | 1 | 0.2 | ns |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 251.096669 | 1 | <0.0001 | *** |
| Study | 1.107622 | 1 | 0.3 | ns |
| f39_gdm_new | 1.386104 | 1 | 0.2 | ns |
| BMI | 87.622496 | 1 | <0.0001 | *** |
| Ethnicity_cauc | 3.246832 | 1 | 0.07 | ns |
| f10c_any_cig_1st_vst | 1.039153 | 1 | 0.3 | ns |
| GA_samp | 1032.266869 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 3.376951 | 1 | 0.07 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 21.326 | 21.326 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 33.726 | 33.726 | <0.0001 | *** |
| 4 | BMI | 1 | Inf | 330.722 | 330.722 | <0.0001 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 25.046 | 25.046 | <0.0001 | *** |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 3.158 | 3.158 | 0.08 | ns |
| 7 | GA_samp | 1 | Inf | 2.506 | 2.506 | 0.1 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 4.089 | 4.089 | 0.04 | * |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 36.051 | 36.051 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 32.027 | 32.027 | <0.0001 | *** |
| 4 | BMI | 1 | Inf | 316.807 | 316.807 | <0.0001 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 24.882 | 24.882 | <0.0001 | *** |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 2.618 | 2.618 | 0.1 | ns |
| 7 | GA_samp | 1 | Inf | 1.602 | 1.602 | 0.2 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 4.361 | 4.361 | 0.04 | * |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 53.182 | 53.182 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 4.345 | 4.345 | 0.04 | * |
| 4 | BMI | 1 | Inf | 11.449 | 11.449 | 0.0007 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 0.718 | 0.718 | 0.4 | ns |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 0.028 | 0.028 | 0.9 | ns |
| 7 | GA_samp | 1 | Inf | 0.278 | 0.278 | 0.6 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 1.558 | 1.558 | 0.2 | ns |
39.1.2 Model Summary
Model summaries.
Prolactin| Var | Effect | P |
|---|---|---|
| (Intercept) | 19.27 (13.37, 27.77) | <0.0001 |
| StudySTOP | 0.91 (0.82, 1.01) | 0.07 |
| f39_gdm_newGDM | 0.93 (0.76, 1.13) | 0.45 |
| BMI | 1.00 (0.99, 1.00) | 0.07 |
| Ethnicity_caucNo | 1.54 (1.42, 1.68) | <0.0001 |
| f10c_any_cig_1st_vstYes | 0.79 (0.73, 0.84) | <0.0001 |
| GA_samp | 1.14 (1.12, 1.17) | <0.0001 |
| StudySTOP:f39_gdm_newGDM | 1.16 (0.94, 1.44) | 0.17 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 3.24 (2.69, 3.91) | <0.0001 |
| StudySTOP | 1.08 (1.02, 1.14) | 0.007 |
| f39_gdm_newGDM | 0.97 (0.88, 1.06) | 0.51 |
| BMI | 0.98 (0.98, 0.98) | <0.0001 |
| Ethnicity_caucNo | 1.05 (1.01, 1.10) | 0.02 |
| f10c_any_cig_1st_vstYes | 1.02 (0.98, 1.06) | 0.34 |
| GA_samp | 1.33 (1.32, 1.35) | <0.0001 |
| StudySTOP:f39_gdm_newGDM | 1.07 (0.96, 1.19) | 0.22 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.12 (0.09, 0.16) | <0.0001 |
| StudySTOP | 0.96 (0.89, 1.04) | 0.29 |
| f39_gdm_newGDM | 0.92 (0.79, 1.06) | 0.24 |
| BMI | 0.99 (0.98, 0.99) | <0.0001 |
| Ethnicity_caucNo | 1.06 (0.99, 1.13) | 0.07 |
| f10c_any_cig_1st_vstYes | 1.03 (0.98, 1.08) | 0.31 |
| GA_samp | 1.29 (1.27, 1.31) | <0.0001 |
| StudySTOP:f39_gdm_newGDM | 1.16 (0.99, 1.36) | 0.07 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 2.65 (1.67, 4.18) | <0.0001 |
| StudySTOP | 0.76 (0.66, 0.88) | 0.0002 |
| f39_gdm_newGDM | 1.71 (1.36, 2.16) | <0.0001 |
| BMI | 1.05 (1.05, 1.06) | <0.0001 |
| Ethnicity_caucNo | 1.37 (1.21, 1.56) | <0.0001 |
| f10c_any_cig_1st_vstYes | 0.92 (0.83, 1.01) | 0.08 |
| GA_samp | 1.02 (0.99, 1.05) | 0.11 |
| StudySTOP:f39_gdm_newGDM | 0.76 (0.58, 0.99) | 0.04 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.63 (0.39, 1.02) | 0.06 |
| StudySTOP | 0.65 (0.56, 0.76) | <0.0001 |
| f39_gdm_newGDM | 1.84 (1.40, 2.42) | <0.0001 |
| BMI | 1.05 (1.05, 1.06) | <0.0001 |
| Ethnicity_caucNo | 1.40 (1.22, 1.59) | <0.0001 |
| f10c_any_cig_1st_vstYes | 0.92 (0.83, 1.02) | 0.11 |
| GA_samp | 1.02 (0.99, 1.05) | 0.21 |
| StudySTOP:f39_gdm_newGDM | 0.72 (0.53, 0.98) | 0.04 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 5.23 (4.75, 5.75) | <0.0001 |
| StudySTOP | 0.87 (0.84, 0.89) | <0.0001 |
| f39_gdm_newGDM | 1.10 (0.99, 1.22) | 0.09 |
| BMI | 1.00 (1.00, 1.00) | 0.0007 |
| Ethnicity_caucNo | 1.01 (0.99, 1.03) | 0.40 |
| f10c_any_cig_1st_vstYes | 1.00 (0.98, 1.02) | 0.87 |
| GA_samp | 1.00 (0.99, 1.00) | 0.60 |
| StudySTOP:f39_gdm_newGDM | 0.93 (0.84, 1.04) | 0.21 |
39.1.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/L)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
39.1.4 Results
39.1.4.1 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling, BMI, ethnicity and smoking.
em_eq <- as.formula(paste0("pairwise~Study*",outc2))
#fit_em <- lapply(fit_ls,function(x){emmeans(x,em_eq,type="response")})
fit_em <- foreach(ind2=1:length(fit_ls),.packages=c("foreach","lme4","lmerTest","geepack","emmeans")) %dopar% {
emmeans(fit_ls[[ind2]],em_eq,type="response",lmer.df="satterthwaite")}
names(fit_em) <- names(fit_ls)
fit_em_contrasts <- lapply(fit_em,function(x){
contrast_dat <- data.frame(x$emmeans)
contrast_dat$Group <- with(contrast_dat,paste(Study,get(outc2),sep="."))
contrast_mat <- diag(nrow(contrast_dat))
rownames(contrast_mat) <- colnames(contrast_mat) <- contrast_dat$Group
contrast_ls <- list(
"STOP/SCOPE (non-cases)"=contrast_mat[paste0("STOP.",preg_out_label[1]),]-contrast_mat[paste0("SCOPE.",preg_out_label[1]),],
"STOP/SCOPE (Cases)"=contrast_mat[paste0("STOP.",preg_out_label[2]),]-contrast_mat[paste0("SCOPE.",preg_out_label[2]),],
"Cases/non-cases (SCOPE)"=contrast_mat[paste0("SCOPE.",preg_out_label[2]),]-contrast_mat[paste0("SCOPE.",preg_out_label[1]),],
"Cases/non-cases (STOP)"=contrast_mat[paste0("STOP.",preg_out_label[2]),]-contrast_mat[paste0("STOP.",preg_out_label[1]),])
names(contrast_ls) <- c("STOP/SCOPE (non-cases)",paste0("STOP/SCOPE (",outc2,")"),
paste0(outc2,"/non-cases (SCOPE)"),paste0(outc2,"/non-cases (STOP)"))
contrast_out <- contrast(x$emmeans,method=contrast_ls)
return(contrast_out)})| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 111.0154 | 8.681308 | 96.52335 | 95.05499 | 129.6557 |
| STOP | non-GDM | 101.0402 | 7.521753 | 79.44826 | 87.12606 | 117.1765 |
| SCOPE | GDM | 102.8206 | 12.570919 | 488.73126 | 80.86360 | 130.7395 |
| STOP | GDM | 108.6664 | 9.407853 | 142.31669 | 91.57354 | 128.9498 |
| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 92.79956 | 2.631487 | 208.5170 | 87.75417 | 98.13503 |
| STOP | non-GDM | 100.16214 | 2.580611 | 143.9125 | 95.18905 | 105.39505 |
| SCOPE | GDM | 89.90620 | 4.703155 | 855.7065 | 81.13321 | 99.62781 |
| STOP | GDM | 103.60960 | 3.630797 | 403.1080 | 96.71224 | 110.99886 |
| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 2.447434 | 0.0797623 | 643.5290 | 2.295715 | 2.609181 |
| STOP | non-GDM | 2.348242 | 0.0646686 | 403.7659 | 2.224493 | 2.478876 |
| SCOPE | GDM | 2.244898 | 0.1698300 | 1454.2571 | 1.935300 | 2.604024 |
| STOP | GDM | 2.502546 | 0.1064317 | 815.6024 | 2.302116 | 2.720426 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 16.13732 | 0.9237574 | Inf | 14.42466 | 18.05332 |
| STOP | non-GDM | 12.27648 | 0.5729224 | Inf | 11.20340 | 13.45235 |
| SCOPE | GDM | 27.63445 | 3.3537549 | Inf | 21.78451 | 35.05531 |
| STOP | GDM | 15.99781 | 1.1514391 | Inf | 13.89299 | 18.42153 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 3.941501 | 0.2407589 | Inf | 3.496775 | 4.442789 |
| STOP | non-GDM | 2.576228 | 0.1260619 | Inf | 2.340629 | 2.835541 |
| SCOPE | GDM | 7.264465 | 1.0212704 | Inf | 5.514904 | 9.569060 |
| STOP | GDM | 3.432514 | 0.2659047 | Inf | 2.948986 | 3.995322 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 5.455388 | 0.0606409 | Inf | 5.337820 | 5.575546 |
| STOP | non-GDM | 4.732806 | 0.0383650 | Inf | 4.658206 | 4.808600 |
| SCOPE | GDM | 5.997698 | 0.3022740 | Inf | 5.433572 | 6.620392 |
| STOP | GDM | 4.855922 | 0.0646889 | Inf | 4.730775 | 4.984380 |
39.1.4.2 Comparisons
Prolactin| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases) | 0.910 | 0.048 | 2134.356 | 0.821 | 1.009 | 0.073 | ns |
| STOP/SCOPE (f39_gdm_new) | 1.057 | 0.121 | 1848.804 | 0.845 | 1.322 | 0.628 | ns |
| f39_gdm_new/non-cases (SCOPE) | 0.926 | 0.094 | 1760.115 | 0.760 | 1.129 | 0.448 | ns |
| f39_gdm_new/non-cases (STOP) | 1.075 | 0.057 | 2124.426 | 0.969 | 1.193 | 0.170 | ns |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases) | 1.079 | 0.030 | 2146.493 | 1.022 | 1.140 | 0.007 | ** |
| STOP/SCOPE (f39_gdm_new) | 1.152 | 0.065 | 1454.099 | 1.031 | 1.288 | 0.012 | * |
| f39_gdm_new/non-cases (SCOPE) | 0.969 | 0.046 | 1008.430 | 0.882 | 1.064 | 0.509 | ns |
| f39_gdm_new/non-cases (STOP) | 1.034 | 0.030 | 2143.118 | 0.978 | 1.094 | 0.238 | ns |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases) | 0.959 | 0.038 | 2093.891 | 0.888 | 1.036 | 0.293 | ns |
| STOP/SCOPE (f39_gdm_new) | 1.115 | 0.095 | 1805.358 | 0.944 | 1.317 | 0.201 | ns |
| f39_gdm_new/non-cases (SCOPE) | 0.917 | 0.067 | 1602.268 | 0.794 | 1.059 | 0.239 | ns |
| f39_gdm_new/non-cases (STOP) | 1.066 | 0.042 | 2020.496 | 0.986 | 1.152 | 0.110 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases) | 0.761 | 0.055 | Inf | 0.660 | 0.877 | 0.0002 | *** |
| STOP/SCOPE (f39_gdm_new) | 0.579 | 0.081 | Inf | 0.440 | 0.762 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE) | 1.712 | 0.202 | Inf | 1.358 | 2.159 | <0.0001 | *** |
| f39_gdm_new/non-cases (STOP) | 1.303 | 0.089 | Inf | 1.139 | 1.491 | 0.0001 | *** |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases) | 0.654 | 0.050 | Inf | 0.562 | 0.760 | <0.0001 | *** |
| STOP/SCOPE (f39_gdm_new) | 0.473 | 0.075 | Inf | 0.346 | 0.646 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE) | 1.843 | 0.255 | Inf | 1.405 | 2.418 | <0.0001 | *** |
| f39_gdm_new/non-cases (STOP) | 1.332 | 0.098 | Inf | 1.153 | 1.540 | 0.0001 | *** |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases) | 0.868 | 0.013 | Inf | 0.843 | 0.893 | <0.0001 | *** |
| STOP/SCOPE (f39_gdm_new) | 0.810 | 0.040 | Inf | 0.734 | 0.893 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE) | 1.099 | 0.061 | Inf | 0.987 | 1.225 | 0.086 | ns |
| f39_gdm_new/non-cases (STOP) | 1.026 | 0.013 | Inf | 1.001 | 1.052 | 0.043 | * |
39.1.5 Comparisons by Timepoint
Prolactin| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases)|10wks | 0.910 | 0.048 | 2134.356 | 0.821 | 1.009 | 0.073 | ns |
| STOP/SCOPE (f39_gdm_new)|10wks | 1.057 | 0.121 | 1848.804 | 0.845 | 1.322 | 0.628 | ns |
| f39_gdm_new/non-cases (SCOPE)|10wks | 0.926 | 0.094 | 1760.115 | 0.760 | 1.129 | 0.448 | ns |
| f39_gdm_new/non-cases (STOP)|10wks | 1.075 | 0.057 | 2124.426 | 0.969 | 1.193 | 0.170 | ns |
| STOP/SCOPE (non-cases)|16wks | 0.910 | 0.048 | 2134.356 | 0.821 | 1.009 | 0.073 | ns |
| STOP/SCOPE (f39_gdm_new)|16wks | 1.057 | 0.121 | 1848.804 | 0.845 | 1.322 | 0.628 | ns |
| f39_gdm_new/non-cases (SCOPE)|16wks | 0.926 | 0.094 | 1760.115 | 0.760 | 1.129 | 0.448 | ns |
| f39_gdm_new/non-cases (STOP)|16wks | 1.075 | 0.057 | 2124.426 | 0.969 | 1.193 | 0.170 | ns |
| 16wks/10wks (non-cases)|SCOPE | 2.234 | 0.140 | 2126.990 | 1.976 | 2.526 | <0.0001 | *** |
| 16wks/10wks (f39_gdm_new)|SCOPE | 2.234 | 0.140 | 2126.990 | 1.976 | 2.526 | <0.0001 | *** |
| 16wks/10wks (non-cases)|STOP | 2.234 | 0.140 | 2126.990 | 1.976 | 2.526 | <0.0001 | *** |
| 16wks/10wks (f39_gdm_new)|STOP | 2.234 | 0.140 | 2126.990 | 1.976 | 2.526 | <0.0001 | *** |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases)|10wks | 1.079 | 0.030 | 2146.493 | 1.022 | 1.140 | 0.007 | ** |
| STOP/SCOPE (f39_gdm_new)|10wks | 1.152 | 0.065 | 1454.099 | 1.031 | 1.288 | 0.012 | * |
| f39_gdm_new/non-cases (SCOPE)|10wks | 0.969 | 0.046 | 1008.430 | 0.882 | 1.064 | 0.509 | ns |
| f39_gdm_new/non-cases (STOP)|10wks | 1.034 | 0.030 | 2143.118 | 0.978 | 1.094 | 0.238 | ns |
| STOP/SCOPE (non-cases)|16wks | 1.079 | 0.030 | 2146.493 | 1.022 | 1.140 | 0.007 | ** |
| STOP/SCOPE (f39_gdm_new)|16wks | 1.152 | 0.065 | 1454.099 | 1.031 | 1.288 | 0.012 | * |
| f39_gdm_new/non-cases (SCOPE)|16wks | 0.969 | 0.046 | 1008.430 | 0.882 | 1.064 | 0.509 | ns |
| f39_gdm_new/non-cases (STOP)|16wks | 1.034 | 0.030 | 2143.118 | 0.978 | 1.094 | 0.238 | ns |
| 16wks/10wks (non-cases)|SCOPE | 5.598 | 0.189 | 2130.600 | 5.240 | 5.982 | <0.0001 | *** |
| 16wks/10wks (f39_gdm_new)|SCOPE | 5.598 | 0.189 | 2130.600 | 5.240 | 5.982 | <0.0001 | *** |
| 16wks/10wks (non-cases)|STOP | 5.598 | 0.189 | 2130.600 | 5.240 | 5.982 | <0.0001 | *** |
| 16wks/10wks (f39_gdm_new)|STOP | 5.598 | 0.189 | 2130.600 | 5.240 | 5.982 | <0.0001 | *** |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases)|10wks | 0.959 | 0.038 | 2093.891 | 0.888 | 1.036 | 0.293 | ns |
| STOP/SCOPE (f39_gdm_new)|10wks | 1.115 | 0.095 | 1805.358 | 0.944 | 1.317 | 0.201 | ns |
| f39_gdm_new/non-cases (SCOPE)|10wks | 0.917 | 0.067 | 1602.268 | 0.794 | 1.059 | 0.239 | ns |
| f39_gdm_new/non-cases (STOP)|10wks | 1.066 | 0.042 | 2020.496 | 0.986 | 1.152 | 0.110 | ns |
| STOP/SCOPE (non-cases)|16wks | 0.959 | 0.038 | 2093.891 | 0.888 | 1.036 | 0.293 | ns |
| STOP/SCOPE (f39_gdm_new)|16wks | 1.115 | 0.095 | 1805.358 | 0.944 | 1.317 | 0.201 | ns |
| f39_gdm_new/non-cases (SCOPE)|16wks | 0.917 | 0.067 | 1602.268 | 0.794 | 1.059 | 0.239 | ns |
| f39_gdm_new/non-cases (STOP)|16wks | 1.066 | 0.042 | 2020.496 | 0.986 | 1.152 | 0.110 | ns |
| 16wks/10wks (non-cases)|SCOPE | 4.641 | 0.222 | 2163.793 | 4.226 | 5.097 | <0.0001 | *** |
| 16wks/10wks (f39_gdm_new)|SCOPE | 4.641 | 0.222 | 2163.793 | 4.226 | 5.097 | <0.0001 | *** |
| 16wks/10wks (non-cases)|STOP | 4.641 | 0.222 | 2163.793 | 4.226 | 5.097 | <0.0001 | *** |
| 16wks/10wks (f39_gdm_new)|STOP | 4.641 | 0.222 | 2163.793 | 4.226 | 5.097 | <0.0001 | *** |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases)|10wks | 0.761 | 0.055 | Inf | 0.660 | 0.877 | 0.0002 | *** |
| STOP/SCOPE (f39_gdm_new)|10wks | 0.579 | 0.081 | Inf | 0.440 | 0.762 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE)|10wks | 1.712 | 0.202 | Inf | 1.358 | 2.159 | <0.0001 | *** |
| f39_gdm_new/non-cases (STOP)|10wks | 1.303 | 0.089 | Inf | 1.139 | 1.491 | 0.0001 | *** |
| STOP/SCOPE (non-cases)|16wks | 0.761 | 0.055 | Inf | 0.660 | 0.877 | 0.0002 | *** |
| STOP/SCOPE (f39_gdm_new)|16wks | 0.579 | 0.081 | Inf | 0.440 | 0.762 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE)|16wks | 1.712 | 0.202 | Inf | 1.358 | 2.159 | <0.0001 | *** |
| f39_gdm_new/non-cases (STOP)|16wks | 1.303 | 0.089 | Inf | 1.139 | 1.491 | 0.0001 | *** |
| 16wks/10wks (non-cases)|SCOPE | 1.144 | 0.097 | Inf | 0.968 | 1.352 | 0.113 | ns |
| 16wks/10wks (f39_gdm_new)|SCOPE | 1.144 | 0.097 | Inf | 0.968 | 1.352 | 0.113 | ns |
| 16wks/10wks (non-cases)|STOP | 1.144 | 0.097 | Inf | 0.968 | 1.352 | 0.113 | ns |
| 16wks/10wks (f39_gdm_new)|STOP | 1.144 | 0.097 | Inf | 0.968 | 1.352 | 0.113 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases)|10wks | 0.654 | 0.050 | Inf | 0.562 | 0.760 | <0.0001 | *** |
| STOP/SCOPE (f39_gdm_new)|10wks | 0.473 | 0.075 | Inf | 0.346 | 0.646 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE)|10wks | 1.843 | 0.255 | Inf | 1.405 | 2.418 | <0.0001 | *** |
| f39_gdm_new/non-cases (STOP)|10wks | 1.332 | 0.098 | Inf | 1.153 | 1.540 | 0.0001 | *** |
| STOP/SCOPE (non-cases)|16wks | 0.654 | 0.050 | Inf | 0.562 | 0.760 | <0.0001 | *** |
| STOP/SCOPE (f39_gdm_new)|16wks | 0.473 | 0.075 | Inf | 0.346 | 0.646 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE)|16wks | 1.843 | 0.255 | Inf | 1.405 | 2.418 | <0.0001 | *** |
| f39_gdm_new/non-cases (STOP)|16wks | 1.332 | 0.098 | Inf | 1.153 | 1.540 | 0.0001 | *** |
| 16wks/10wks (non-cases)|SCOPE | 1.121 | 0.101 | Inf | 0.939 | 1.337 | 0.206 | ns |
| 16wks/10wks (f39_gdm_new)|SCOPE | 1.121 | 0.101 | Inf | 0.939 | 1.337 | 0.206 | ns |
| 16wks/10wks (non-cases)|STOP | 1.121 | 0.101 | Inf | 0.939 | 1.337 | 0.206 | ns |
| 16wks/10wks (f39_gdm_new)|STOP | 1.121 | 0.101 | Inf | 0.939 | 1.337 | 0.206 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| STOP/SCOPE (non-cases)|10wks | 0.868 | 0.013 | Inf | 0.843 | 0.893 | <0.0001 | *** |
| STOP/SCOPE (f39_gdm_new)|10wks | 0.810 | 0.040 | Inf | 0.734 | 0.893 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE)|10wks | 1.099 | 0.061 | Inf | 0.987 | 1.225 | 0.086 | ns |
| f39_gdm_new/non-cases (STOP)|10wks | 1.026 | 0.013 | Inf | 1.001 | 1.052 | 0.043 | * |
| STOP/SCOPE (non-cases)|16wks | 0.868 | 0.013 | Inf | 0.843 | 0.893 | <0.0001 | *** |
| STOP/SCOPE (f39_gdm_new)|16wks | 0.810 | 0.040 | Inf | 0.734 | 0.893 | <0.0001 | *** |
| f39_gdm_new/non-cases (SCOPE)|16wks | 1.099 | 0.061 | Inf | 0.987 | 1.225 | 0.086 | ns |
| f39_gdm_new/non-cases (STOP)|16wks | 1.026 | 0.013 | Inf | 1.001 | 1.052 | 0.043 | * |
| 16wks/10wks (non-cases)|SCOPE | 0.990 | 0.019 | Inf | 0.954 | 1.027 | 0.598 | ns |
| 16wks/10wks (f39_gdm_new)|SCOPE | 0.990 | 0.019 | Inf | 0.954 | 1.027 | 0.598 | ns |
| 16wks/10wks (non-cases)|STOP | 0.990 | 0.019 | Inf | 0.954 | 1.027 | 0.598 | ns |
| 16wks/10wks (f39_gdm_new)|STOP | 0.990 | 0.019 | Inf | 0.954 | 1.027 | 0.598 | ns |